The Negative Effects of Clomid Treatment on Men's SHBG and Free Testosterone Levels

In recent years, there has been an increasing interest in fertility treatments for men, with Clomid (clomiphene citrate) being one of the most commonly prescribed medications. While Clomid has shown effectiveness in stimulating ovulation in women, its use in men has raised concerns regarding its impact on sex hormone-binding globulin (SHBG) and free testosterone levels. In this blog post, we will delve into the negative effects that Clomid treatment can have on men’s SHBG and free testosterone levels.

Understanding SHBG and Free Testosterone:

Before discussing the effects of Clomid, it is crucial to understand the roles of SHBG and free testosterone in the male body. SHBG is a protein that binds to testosterone, limiting its availability for biological activity. Free testosterone, on the other hand, is the fraction of testosterone that is not bound to SHBG and is biologically active. Free testosterone plays a crucial role in various physiological functions, including sexual health, muscle mass maintenance, mood regulation, and overall well-being.

Negative Effects of Clomid Treatment:

  1. Increased SHBG Levels: Studies have shown that Clomid treatment in men can lead to a significant increase in SHBG levels. This rise in SHBG can result in more testosterone being bound and rendered inactive, reducing the available pool of free testosterone. As a result, individuals may experience a decrease in libido, energy levels, and overall sexual function.

  2. Decreased Free Testosterone: With the rise in SHBG levels, the concentration of free testosterone is often diminished. This decline can have detrimental effects on men’s physical and mental well-being. Symptoms such as fatigue, decreased muscle mass, reduced bone density, and mood disturbances can be observed.

  3. Impact on Fertility: Paradoxically, while Clomid is prescribed to enhance fertility in men, the increase in SHBG and subsequent decrease in free testosterone levels may interfere with the reproductive process. Testosterone is necessary for sperm production, and reduced levels can negatively affect sperm quality and quantity, potentially hindering the chances of successful conception.

  4. Psychological Effects: Testosterone plays a crucial role in mood regulation, and any disturbance in its levels can impact psychological well-being. Decreased free testosterone levels can contribute to symptoms such as depression, irritability, decreased motivation, and a general decrease in quality of life.


While Clomid has been widely used in fertility treatments for both women and men, it is important to be aware of its potential negative effects on SHBG and free testosterone levels in men. The increase in SHBG and subsequent decrease in free testosterone can have significant implications for sexual health, fertility, physical well-being, and mental health. Therefore, individuals considering Clomid treatment should consult with a qualified healthcare professional who can provide guidance, monitor hormone levels, and develop an appropriate treatment plan tailored to their specific needs.